The Role of Intestinal Bacteria in the Transformation of Sodium Picosulfate
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概要
- 論文の詳細を見る
Sodium picosulfate, a laxative, was biotransformed to 4, 4-dihydroxydiphenyl-(2 pyridyl)-methane by intestinal flora that produced a novel sulfotransferase (not sulfatase). The biotransformation was activated by adding phenolic compounds such as phenol, acetaminophen and flavonoids. The enzyme activity related to this biotransformation was the highest in the contents of the caecum region of the intestine. The enzyme activity was 3.0 μmole/hr/g wet feces in humans and 0.75 in rats (pH 8.0). The optimal pH was 9.0.
著者
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Kim Dong-hyun
Department Of Animal Science Utsunomiya University
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Kim Dong-Hyun
Department of Microbiology, College of Pharmacy, Kyung-Hee University
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KOBASHI Kyoichi
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Shim Sang-Bum
Department of Microbiology, College of Pharmacy, Kyung-Hee University
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Hyun Sung-Hae
Department of Microbiology, College of Pharmacy, Kyung-Hee University
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