EFFECTS OF DIMORPHOLAMINE ON FROG SCIATIC NERVE-SARTORIUS PREPARATION

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概要

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• The present study describes the potentiating effect of dimorpholamine on twitch contraction of skeletal muscle and its mechanism on a cellular basis. Low concentrations (about 2×10<SUP>-5</SUP> g/ml) of dimorpholamine potentiate the twitch contraction of frog sartorius muscle. In relatively high concentrations of 10<SUP>-4</SUP>-10<SUP>-3</SUP> g/ml, however, the potentiation was followed by depression. Endplate potential was not affected by the drug. Dimorpholamine depolarized slightly the muscle membrane. The contracture tension <I>vs</I>. membrane potential relationship was hardly affected by the drug in the presence of 2×10<SUP>-7</SUP> M tetrodotoxin. Action potentials recorded from muscle fibers treated with ethylene glycol showed marked and progressive increases in duration during exposure to the drug, and were finally blocked. It was concluded that twitch potentiation caused by dimorpholamine is due to the prolongation of the action potential. A likely molecular mechanism of this drug is discussed in terms of the kinetic model proposed by Adrian <I>et al</I>. (J. Physiol. 208, 607-644, 1970) for the excitable membrane of frog sartorius muscle.

• 社団法人 日本薬理学会の論文

著者

• HIRONAKA Tetsuji

  Department of Pharmacology, Teikyo University School of Medicine

• MORIMOTO Shoji

  Department of Pharmacology, Teikyo University School of Medicine

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• IONIC MECHANISM OF THE RESTING MEMBRANE DEPOLARIZATION OF FROG SARTORIUS MUSCLE INDUCED BY DIMORPHOLAMINE
• EFFECTS OF DIMORPHOLAMINE ON FROG SCIATIC NERVE-SARTORIUS PREPARATION
• A method for measuring resting and action potentials with external electrodes in crayfish giant axons
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