STUDIES ON THE FUNCTION OF CELL MEMBRANE 11th REPORT: BINDING OF CYTOCHROME b<SUB>5</SUB> TO LIVER MICROSOMES AND PLASMA MEMBRANES ISOLATED FROM NORMAL AND CCl<SUB>4</SUB>-TREATED RATS

スポンサーリンク

概要

• 論文の詳細を見る

• Cytochrome b<SUB>5</SUB> was isolated from liver microsomes using a detergent-method. The hemoprotein was found to bind to liver plasma membranes <I>in vitro</I> and was accompanied by an increase in NADH-cytochrome c reductase activity, but not NADH-ferricyanide reductase activity. As in the case of microsomes, the binding to plasma membranes was temperature-dependent and was tight to the extent that the bound cytochrome b<SUB>5</SUB> was little released under high ionic strength. The capacity of plasma membranes for the binding was less than that of microsomes. Administration of CCl<SUB>4</SUB> did not significantly affect the binding of the hemoprotein in both fractions. These results add support to our previous proposal that the elevation of NADH-cytochrome c reductase activity of liver plasma membranes observed early after administration of CCl<SUB>4</SUB> may be caused by the binding of cytochrome b<SUB>5</SUB> which has probably migrated from the endoplasmic reticulum.

• 社団法人 日本薬理学会の論文

著者

• MURANO Tadashi

  Research Institute for Medical Sciences, Wakayama Medical College

• MASUDA Yasusuke

  Research Institute for Medical Sciences, Wakayama Medical College

関連論文

• ANTAGONISM BY NALOXONE OF TOLERANCE AND DEPENDENCE IN MICE GIVEN A SINGLE DOSE OF MORPHINE
• STUDIES ON THE FUNCTION OF CELL MEMBRANE 10TH REPORT : EFFECTS OF CCl4 ON THE MARKER ENZYME ACTIVITIES AND FINE STRUCTURES OF RAT LIVER PLASMA MEMBRANES AND MICROSOMES IN VITRO
• STUDIES ON THE FUNCTION OF CELL MEMBRANE 11th REPORT: BINDING OF CYTOCHROME b5 TO LIVER MICROSOMES AND PLASMA MEMBRANES ISOLATED FROM NORMAL AND CCl4-TREATED RATS
• EFFECT OF LINOLEIC ACID HYDROPEROXIDE ON LIVER MICROSOMAL ENZYMES IN VITRO

スポンサーリンク