EFFECTS OF CENTRALLY AFFECTING DRUGS ON THE DIURETIC AND ANTIDIURETIC ACTIONS OF INTRACEREBROVENTRICULAR PROSTAGLANDIN E<SUB>2</SUB>
スポンサーリンク
概要
- 論文の詳細を見る
Effects of centrally affecting drugs on the diuretic and antidiuretic actions of intracerebroventricularly (i.c.v.) injected prostaglandin (PG) E<SUB>2</SUB> in ethanol-anaesthetized rats were studied. PGE<SUB>2</SUB>, when injected i.c.v. at a dose of 1 nmole, produced diuresis followed by antidiuresis. When morphine (0.1 mM) was perfused i.c.v., urine outflow decreased and neither diuretic nor antidiuretic effects of i.c.v. PGE<SUB>2</SUB> was apparent. The perfusions with picrotoxin, γ-aminobutyric acid and L-glutamate inhibited either the diuretic or the antidiuretic effect of PGE<SUB>2</SUB>. On the other hand, when pentobarbital, diazepam, isoniazid and strychnine were perfused i.c.v., the diuretic action of PGE<SUB>2</SUB> was diminished and antidiuresis in response to PGE<SUB>2</SUB> remained unchanged. These results suggested that the diuretic and antidiuretic effects of PGE<SUB>2</SUB> could be separated. The development of the diuretic effect of PGE<SUB>2</SUB> was completely blocked by amitriptyline and antidiuresis was increased. In rats pretreated i.c.v. with reserpine, the diuretic effect of PGE<SUB>2</SUB> was prolonged and antidiuresis in response to PGE<SUB>2</SUB> was not observed. An antidiuretic action of i.c.v. norepinephrine was not varied by reserpine. Mechanisms for both effects of PGE<SUB>2</SUB> are discussed.
- 社団法人 日本薬理学会の論文
著者
-
Fujimoto Seigo
Department Of Cellular And Molecular Pharmacology Nagoya City University Graduate School Of Medical
-
Hisada Shiro
Department Of Pharmacology Nagoya City University Medical School
関連論文
- Role of Rho/Rho-Kinase and NO/cGMP Signaling Pathways in Vascular Function Prior to Atherosclerosis
- α-Adrenoceptor Subtype in the Hypothalamic Paraventricular Nucleus Involved in the Regulation of Urine Production: Comparison between Wistar Kyoto and Spontaneously Hypertensive Rats
- EFFECTS OF GLUTAMIC ACID ANALOGUES ON THE BLOOD LEVEL OF ANTIDIURETIC HORMONE IN DOGS WITH A PROPOSED MEASUREMENT OF THE ANTIDIURETIC ACTIVITY
- THE OXYTOCIC EFFECT OF CENTRALLY INJECTED PROSTAGLANDINS E2 AND F2α
- ISOLATION OF γ-AMINOBUTYRIC ACID FROM BACTERIAL METABOLITES
- STUDIES ON THE ACTION OF NEW ANTIHISTAMINICS : CHEMICAL CONSTITUTION AND PHARMACOLOGICAL ACTION OF THE DERIVATIVES OF HALOGEN-CONTAINING BENZHYDRYLAMINE
- ON THE EFFECTS OF CARDIAC GLYCOSIDES ON THE RESPIRATION OF HEART MUSCLE
- EFFECTS OF HYDROCORTISONE AND PREDNISOLONE ON THE DIURETIC AND ANTIDIURETIC EFFECTS OF PROSTAGLANDIN E2 IN RATS
- EFFECTS OF CENTRALLY AFFECTING DRUGS ON THE DIURETIC AND ANTIDIURETIC ACTIONS OF INTRACEREBROVENTRICULAR PROSTAGLANDIN E2
- EFFECTS OF INTRACEREBROVENTRICULAR PROSTAGLANDINS E2 AND F2α ON THE URINE OUTFLOW, AND A POSSIBLE ROLE OF PGE2 AS A MODULATOR
- POLY-AND DI-PHLORETIN PHOSPHATE-INDUCED ALTERATIONS ON DIURESIS AND ANTIDIURESIS IN RESPONSE TO 1NTRACEREBROVENTRICULAR PROSTAGLANDIN A2
- CENTRALLY-MEDIATED EFFECTS OF PROSTAGLANDIN A2 ON URINE OUTFLOW
- RELATIVE INFLUENCE OF ANAESTHETICS ON DEPRESSOR EFFECTS OF INTRAVENOUS PROSTAGLANDINS E2 AND A2
- INHIBITION BY PICROTOXIN OF THERMOGENIC EFFECT OF CENTRALLY-APPLIED PROSTAGLANDIN E2 IN ETHANOL ANAESTHETIZED RATS
- ANTIDIURESIS OF CENTRALLY ADMINISTERED AMINES AND PEPTIDES AND RELEASE OF ANTIDIURETIC HORMONE FROM ISOLATED RAT NEUROHYPOPHYSIS
- EFFECTS OF THE DERIVATIVES OF HALOGEN-CONTAINING BENZHYDRYLETHER ON VOLUNTARY ACTIVITY IN MICE
- EFFECT OF TAURINE ON RESPONSES TO NORADRENALINE, ACETYLCHOLINE AND OUABAIN IN ISOLATED AURICLES FROM DIGITALIZED GUINEA PIGS
- Diminished β1-Adrenoceptor Mediated Relaxation in the Arteries of SHR
- Effects of .BETA.1- and .BETA.2-Adrenoceptor Agonists Applied into the Hypothalamic Paraventricular Nuclei of Spontaneously Hypertensive Rats on Urine Production.