EFFECTS OF INTRACEREBROVENTRICULAR PROSTAGLANDINS E<SUB>2</SUB> AND F<SUB>2α</SUB> ON THE URINE OUTFLOW, AND A POSSIBLE ROLE OF PGE<SUB>2</SUB> AS A MODULATOR
スポンサーリンク
概要
- 論文の詳細を見る
Effects of intracerebroventricularly (i.c.v.) injected PGE<SUB>2</SUB> and PGF<SUB>2α</SUB> on the urine outflow were studied in ethanol-anaesthetized rats. PGE<SUB>2</SUB> and PGF<SUB>2α</SUB>, when injected i.c.v., caused dieresis which was followed by antidiuresis. Phentolamine, when perfused i.c.v., was an antidiuretic and inhibited the diuretic and antidiuretic effects of PGE<SUB>2</SUB>. Diphloretin phosphate inhibited both effects of PGE<SUB>2</SUB>. Polyphloretin phosphate (PPP) and propranolol blocked completely the PGE<SUB>2</SUB>-induced diuresis and consequently remarkable antidiuresis was observed after the combined treatments with PGE<SUB>2</SUB> and PPP or propranolol. When PGE<SUB>2</SUB> was perfused i.c.v., a sustained diuresis was obtained and antidiuretic effects of noradrenaline, γ-aminobutyric acid and L-glutamate were potentiated, inhibited and unaffected by the perfusion with PGE<SUB>2</SUB>, respectively. It was indicated that the antidiuretic effect of PGE<SUB>2</SUB> could be dissociated from the diuretic effect and that both effects were mediated through adrenergic mechanisms. The present result also suggested that central PGE<SUB>2</SUB> might act as a modulator of some neurotransmitters involved in water metabolism.
- 社団法人 日本薬理学会の論文
著者
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Fujimoto Seigo
Department Of Cellular And Molecular Pharmacology Nagoya City University Graduate School Of Medical
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Hisada Shiro
Department Of Pharmacology Nagoya City University Medical School
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