PROSTAGLANDIN SYNTHETASE SYSTEMS IN RAT AND RABBIT RENAL MEDULLA AND INHIBITION BY NON-STEROIDAL ANTI-INFLAMMATORY DRUGS
スポンサーリンク
概要
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The properties of prostaglandin synthetase systems (PSSs) in the renal medulla of the rat and rabbit, and inhibition by ketoprofen, indomethacin, ibuprofen, phenylbutazone and aspirin were investigated in relation to their anti-inflammatory, analgesic, antipyretic and ulcerogenic activities. Rat and rabbit PSSs produced prostaglandin (PG)E and PGF from arachidonic and dihomo-γ-linolenic acids and had an optimal pH of 8.5 and 7.5 for PGE formation, respectively. Only a slight loss of activity occurred with lyophilization. In the rat PSS. all drugs tested were inhibitory in the order of ketoprofen, ibuprofen, indomethacin and aspirin, respectively. In the rabbit PSS, the same potency relationship was also found. Drug sensitivity of the rat PSS was remarkably lower than that of the rabbit PSS. Significant correlations were noted between the inhibitory potencies of the drugs against both PSSs and other <I>in vivo</I> pharmacological activities within the same species.
- 社団法人 日本薬理学会の論文
著者
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Akimoto Takeshi
Research Institute Daiichi Seiyaku Co. Ltd
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SAITO Tadashi
Research and Development Group, Oki Electric Industry Co., Lid.
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TACHIZAWA Haruo
Research Institute, Daiichi Seiyaku Co., Ltd.
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TSUKADA Wataru
Research Institute, Daiichi Seiyaku Co., Ltd.
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Saito Tadashi
Research And Development Group Oki Electric Industry Co. Lid.
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SAITO Tadashi
Research Institute, Daiichi Seiyaku Co., Ltd.
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AKIMOTO Takeshi
Research Institute, Daiichi Seiyaku Co., Ltd.
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