A POSSIBLE MODE OF CARDIOVASCULAR ACTIONS OF DOPAMINE IN DOGS

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概要

• 論文の詳細を見る

• A possible mode of cardiovascular actions of dopamine was studied using ephedrine. In the dog pretreated with repeated administrations of ephedrine (total dose, 40 or 80 mg/kg, i.v.) or with combined administrations of ephedrine (total dose, 90 mg/ kg, s.c. and i.v.) and reserpine (2 mg/kg, s.c., 24 hr previously), pressor responses to dopamine were eliminated and reversed to depressor responses whereas depressor responses to dopamine were potentiated. Positive chronotropic effects of dopamine were almost eliminated. Pressor and positive chronotropic effects of tyramine were almost abolished. Sympathomimetic effect of noradrenaline and adrenaline were potentiated while those of isoprenaline were inhibited. In the heart-lung preparation of ephedrine-treated dogs (total dose, 40 mg/kg, i.v.), cardiac stimulating effects of dopamine and tyrarnine were strongly depressed, and those of noradrenaline, adrenaline and isoprenaline were reduced to some extent. In the open-chest dogs, after pretreatment with cocaine (4 mg/kg, i.v.), pressor, positive inotropic and chronotropic effects of noradrenaline were potentiated whilst those of tyramine were inhibited. Those of dopamine were not visibly altered, but depressor, negative chronotropic and inotropic effects of dopamine appeared at small doses. In the ephedrine-pretreated dogs, these sympathomimetic effects of dopamine and tyramine after cocaine were strongly depressed and those of noradrenaline were inhibited to a certain degree. The results obtained with ephedrine suggest that dopamine differs from other catecholamines and tyramine in the mode of cardiovascular actions.

• 社団法人 日本薬理学会の論文

著者

• FURUKAWA TATSUO

  Department of Pharmacology, School of Medicine, Fukuoka University

• Furukawa Tatsuo

  Department Of Pharmacology Fukuoka University School Of Medicine

• NAKAHARA Tamio

  Pharmacology Group, Preclinical Research Center, Tsukuba Research Laboratories, Nippon Glaxo Ltd.,

• ONO Nobufumi

  Pharmaceutical Sciences, Fukuoka University

• MAEDA Yukihide

  Pharmaceutical Sciences, Fukuoka University

• YOSHIHARA Kanji

  Pharmaceutical Sciences, Fukuoka University

• NAKAHARA Tamio

  Pharmaceutical Sciences, Fukuoka University

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