Possible Involvement of Calcium-Calmodulin Pathways in the Positive Chronotropic Response to Angiotensin II on the Canine Cardiac Sympathetic Ganglia
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the ganglionic effects of angiotensin II (Ang II) and the signal transduction involved in the cardiac sympathetic ganglia by the direct administration of agents to the ganglia through the right subclavian artery and monitoring the heart rate as an indicator of the ganglionic function in pithed dogs. Ang II given i.a. caused increases in the heart rate, which was inhibited by the treatment with the AT1-receptor antagonist forasartan, but not by the AT2-receptor antagonist PD-123319. The stimulation by Ang II, but not by acetylcholine, was inhibited after treatment with an inhibitor of phospholipase C, U-73122; a cell-permeant modulator of the Ins(1,4,5)P3 receptors, 2-aminoethoxydiphenyl borate; an intracellular calcium and calcium-associated protein kinase inhibitor, HA-1077; calmodulin (CaM) inhibitor, W-7; Ca2+/CaM-dependent protein kinase II inhibitor, KN-93; a selective protein kinase C inhibitor, calphostin C; and Na+-H+ exchange inhibitor, dimethylamiloride. These results suggest that Ang II stimulates the ganglionic transmission at postsynaptic sites via the activation of AT1 receptor coupled to either activation of phospholipase C, phosphoinositide hydrolysis and subsequent increase in intracellular Ca2+ and activation of protein kinase C and Ca2+/CaM kinase II, although this ganglionic stimulation seems to involve, at least in part, the protein kinases-dependent increase of amiloride-sensitive Na+ inflow.
- 社団法人 日本薬理学会の論文
- 2001-08-01
著者
-
FURUKAWA TATSUO
Department of Pharmacology, School of Medicine, Fukuoka University
-
TOKUNAGA Ryoko
Department of Chemistry, Faculty of Science, Hiroshima University
-
Tokunaga Ryoko
Department Of Chemistry Faculty Of Science Hiroshima University
-
Tokunaga Ryoko
Department Of Pharmacology School Of Medicine Fukuoka University
-
Furukawa Tatsuo
Department Of Pharmacology Fukuoka University School Of Medicine
-
Furukawa Tatsuo
Department Of Pharmacology School Of Medicine Fukuoka University
-
YAMADA Hiromi
Department of Biochemistry, School of medicine, Fukuoka University
-
KUSHIKU Kazushi
Department of Pharmacology, School of Medicine, Fukuoka University
-
YAMADA Katsuhiro
Department of Pharmacology, School of Medicine, Fukuoka University
-
Yamada Katsuhiro
Department Of Pharmacology School Of Medicine Fukuoka University
-
Yamada Hiromi
Department Of Biochemistry School Of Medicine Fukuoka University
-
Kushiku Kazushi
Department Of Pharmacology School Of Medicine Fukuoka University
関連論文
- EXAGGERATED CENTRAL CARDIOVASCULAR RESPONSES TO ANGIOTENSIN II AND RENIN AND INHIBITION BY ORAL TAURINE IN SPONTANEOUSLY HYPERTENSIVE RATS
- The Effect of High Magnetic Field on the Crystal Growth of Benzophenone
- The Effects of High Magnetic Field on the Deposition of Silver
- BEHAVIORAL STUDIES ON CENTRAL DOPAMINERGIC NEURONS : ESPECIALLY JUMPING, RETCHING, BODY SHAKING AND YAWNING BEHAVIOR
- Substitution of Arg Residues for Lys Resudues in a Cationic Anti-Tumor Peptide Containing D-Amino Acids and Cytotoxicities
- Effect of Innovation of D-amino Acids into Novel Anti-Tumor Peptide and Protein on their Conformation and Cytotoxicities
- SUPERFICIAL NEUROENDOCRINE CARCINOMA OF THE ESOPHAGUS
- Possible Involvement of Calcium-Calmodulin Pathways in the Positive Chronotropic Response to Angiotensin II on the Canine Cardiac Sympathetic Ganglia
- SYMPATHOMIMETIC ACTIONS OF RESERPINE ADMINISTERED DURING TREATMENT WITH DOPAMINE IN THE DOG
- EFFECTS OF RUBIDIUM ON BEHAVIORAL RESPONSES TO METHAMPHETAMINE AND TETRABENAZINE
- α-ADRENERGIC BLOCKING AND β-ADRENERGIC AGENTS —ANTIDOTES FOR CYANIDE TOXICITY—
- MODIFICATIONS OF RESPONSES TO ADRENERGIC DRUGS IN ARTERIAL STRIPS BY TREATMENT IN VIVO WITH EPHEDRINE AND RESERPINE
- A POSSIBLE MODE OF CARDIOVASCULAR ACTIONS OF DOPAMINE IN DOGS
- SPECIES DIFFERENCES IN ANTAGONISTIC EFFECT OF MORPHINE AGAINST DEPRESSOR RESPONSE TO DOPAMINE
- CATECHOLAMINES INDUCE NEUROGENIC VASODILATION BY INHIBITING GANGLIONIC TRANSMISSION IN SPINAL DOGS
- EFFECTS OF BROVINCAMINE ON THE AUTONOMIC NERVOUS FUNCTION IN THE DOG AND RAT
- INVOLVEMENT OF VOLTAGE-DEPENDENT Ca^-CHANNEL ACTIVITIES IN PRE AND POSTSYNAPTIC RESPONSES BY PURINE RECEPTOR STIMULATION
- Modulation of ganglionic transmission and drug evaluation at sympathetic ganglia
- IN VIVO DIRECT EFFECTS OF CHOLINERGIC AGENTS ON THE INFERIOR MESENTERIC AND CARDIAC GANGLIA WITH RELATION TO THEIR RECEPTORS IN THE DOG
- A MODIFICATION OF THE BUTANOL EXTRACTION METHOD FOR THE FLUOROMETRIC ASSAY OF 5-HYDROXYTRYPTAMINE IN THE BRAIN
- The Presence of Two Lactic Dehydrogenases in Piricularia oryzae