DIFFERENTIAL SUSCEPTIBILITY OF L CELLS IN THE EXPONENTIAL AND STATIONARY PHASES TO CADMIUM CHLORIDE
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概要
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Comparative studies of the cellular toxicity and uptake of cadmium in L cells in the exponential and stationary phases were done. The LD50 of cadmium chloride to L cells in the exponential and stationary phases was 5.5 and 30.5 μM, respectively and the cadmium content of L cells exposed to 5.5 μM cadmium chloride for 3.5 hr in the exponential and stationary phases was 0.123 and 0.065 μg 10<SUP>6</SUP> cells, respectively. These results suggest that the higher susceptibility of cells in the exponential phase to cadmium may be caused by an increased permeability of the cell membrane to cadmium.
- 社団法人 日本薬理学会の論文
著者
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Okada Hiroaki
Department Of Chemistry Faculty Of Science Kyoto University
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Sato Atsushige
Department Of Biomaterials Science Tokyo Medical & Dental University
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OZAWA Kazuko
Department of Pharmacology, Yokohama City University School of Medicine
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OKADA Hiroaki
Department of Pharmacology, Yokohama City University School of Medicine
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