EFFECT OF ASCOFURANONE ON SERUM LIPIDSOF RATS FED A CHOLESTEROL RICH DIET

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概要

• 論文の詳細を見る

• Ascofuranone, a fungal metabolite, significantly reduced serum lipid levels, when orally administered to male Wistar rats fed a cholesterol rich diet. The treatment also resulted in a marked reduction of hepatic and cardiac cholesterol contents without affecting the body weight gain. The serum albumin/globulin ratio increased significantly in the treated rats. This increase is presumably due to the decrease of β-lipoprotein. The mode of action differentiates from clofibrate in so far as the former effectively prevents hepatic and cardiac cholesterol deposits in the cholesterol feeding rats.

• 社団法人 日本薬理学会の論文

著者

• Suzuki Koji

  Research Laboratories Of Brewing Technology Asahi Breweries Ltd.

• HOSOKAWA Tomoyoshi

  Research Laboratories, Chugai Pharmaceutical Co., Ltd.

• OKUTOMI Tsuneo

  Research Laboratories, Chugai Pharmaceutical Co., Ltd.

• SAWADA Mikio

  Research Laboratories, Chugai Pharmaceutical Co., Ltd.

• ANDO Kunio

  Research Laboratories, Chugai Pharmaceutical Co., Ltd.

• Suzuki Koji

  Research Institute Of Instrumentation Frontier National Institute Of Advanced Industrial Science And

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• EFFECT OF ASCOFURANONE ON SERUM LIPIDSOF RATS FED A CHOLESTEROL RICH DIET

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