INHIBITION OF K-INDUCED TONIC CONTRACTION IN VAS DEFERENS OF GUINEA PIG BY CHLORPROMAZINE AND ITS FREE RADICAL
スポンサーリンク
概要
- 論文の詳細を見る
Inhibitory effects of chlorpromazine (CP) and its free radical (CP•) on the tonic component of the K-contraction of vas deferens isolated from guinea pig were studied by the Magnus method. CP and CP. were equally effective at concentrations higher than 2×10<SUP>-7</SUP> g/ml for selective inhibition of the tonic component in neutral media (pH 7.4). The effect of CP• was 100 times greater than that of CP in acidic media (pH 5.0). These findings can be explained in terms of the increased stability of CP•, since the absorption spectral analysis showed that CP• was apparently stable in acidic media. Among reducing agents studied, 2-mercaptopropionylglycine was the most potent in restorative activity for the above inhibition.
- 社団法人 日本薬理学会の論文
著者
-
MATSUMOTO Hiroshi
Research Institute for Sustainable Humanosphere (RISH), Kyoto University
-
Yamabe Shigeru
Research Institute Kobe College
-
SUZUKI Aritomo
Research Institute, Kobe College, Nishinomiya and Department of Pharmacology, Faculty of Medicine, K
-
SUZUKI Aritomo
Research Institute, Kobe College, Nishinomiya and Department of Pharmacology, Faculty of Medicine, Kobe University
関連論文
- Isosceles-Trapezoidal-Distribution Edge Tapered Array Antenna with Unequal Element Spacing for Solar Power Satellite
- Study of Isosceles Trapezoidal Edge Tapered Phased Array Antenna for Solar Power Station/Satellite(Antennas and Propagation)
- Electrostatic quasi-monochromatic waves in the downstream region of the Earth's bow shock based on Geotail observations
- Synthesis and Biological Evaluation of 7-Hydroxy-3,4-diphenyl-1,2-dihydroisoquinolines as New 4-Hydroxytamoxifen Analogues
- Impacts of Oil Production Decline on Japanese Food Supply : Prospects toward sustainable human societies
- Development of the Virtual Earth's Magnetosphere System (VEMS)
- Feasibility Study on New SPS Concept Utilizing Multiple Satellites in Formation Flight
- Inhibitory Effect of Chlorpromazine on the Myocardial Contractility
- INHIBITION OF K-INDUCED TONIC CONTRACTION IN VAS DEFERENS OF GUINEA PIG BY CHLORPROMAZINE AND ITS FREE RADICAL
- N-Benzylbutanamides as New Potential Herbicides