PHARMACOLOGICAL STUDY OF HYDROXY BIS-[2-(P-CHLOROPHENOXY)-ISOBUTYRIC ACID] ALUMINIUM:[I] THE EFFECT OF HYDROXY BIS-[2-(P-CHLOROPHENOXY)-ISOBUTYRIC ACID] ALUMINIUM ON LIPID METABOLISM IN NORMAL RATS

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The hypolipidemic effect of alfibrate has been studied in normocholesterolemic rats with clofibrate as a reference. At the dosage of 150 mg/kg, 29% increase of liver weight was observed in the alfibrate group and 87% increase in the clofibrate group. Daily administration of alfibrate (150 mg/kg) produced a significant decrease in serum cholesterol (5%) and triglycerides (15%), and liver cholesterol (12%) and triglycerides (23%) with no change in phospholipids and free fatty acids. Like clofibrate, alfibrate exerted a greater effect on lowering the triglyceride level than cholesterol in normocholesterolemic rats. The liver glycogen concentration and glucose tolerance in the alfibrate group were similar to that of control.
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