STUDIES ON AGE DIFFERENCE IN MICE FOR THE ACTIVITY OF DRUG-METABOLIZING ENZYMES OF LIVER MICROSOMES
スポンサーリンク
概要
- 論文の詳細を見る
In previous papers, we reported that the activity of drug-metabolizing enzymes was higher in young female rats than in old female rats and that the duration of hexobarbital anesthesia was shorter in the young females than in the old females (1-3). Moreover, it was observed that the induction of microsomal drug-metabolizing enzymes by phenobarbital was more effective in young rats than in old rats (4, 5).<BR> In the present communication, we wish to report the evidence that, in contrast to the results obtained with rats, clear age difference was not observed in the activity of drug-metabolizing enzymes in mice and there was no clear age difference in the induction of drug-metabolizing enzymes by phenobarbital.
- 社団法人 日本薬理学会の論文
著者
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加藤 隆一
Department of Urology, University of Pittsburgh
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高仲 正
Department of Pharmacology, National Institute of Hygienic Sciences
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小野田 欽一
Department of Pharmacology, National Institute of Hygienic Sciences
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加藤 隆一
Department of Pharmacology and Department of Toxicology, National Institute of Hygienic Sciences
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高仲 正
Department of Pharmacology and Department of Toxicology, National Institute of Hygienic Sciences
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小野田 欽一
Department of Pharmacology and Department of Toxicology, National Institute of Hygienic Sciences
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