EFFECTS OF FACTORS INHIBITING TENSION DEVELOPMENT ON OXYGEN CONSUMPTION OF GUINEA PIG TAENIA COLI IN HIGH K MEDIUM

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Hypertonically added high-potassium induced a tension development in the guinea pig taenia coli, which was composed of two distinct parts, a phasic response and a tonic one (1, 2). The tonic response was dependent on the aerobic breakdown of carbohydrate and was abolished by substrate removal, anoxia, a decrease in temperature, 2, 4-dinitrophenol (DNP), lithium substitution and ouabain. These factors had little or no effect on the phasic response. From these data it was suggested that the phasic response is a passive process, whereas the tonic response is an active one depending on metabolism. A part of this concept is supported by the finding that the application of high K caused an increase in oxygen consumption that accompanies the muscle tension change (3). In the present paper, effects of factors inhibiting tension development, <I>viz</I>. glucose removal, low oxygen, decrease in temperature, DNP and ouabain, on oxygen consumption in high-potassium medium were studied.
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