INFLUENCES OF EXTERNAL MAGNESIUM, BICARBONATE AND PHOSPHATE ON POTASSIUM-INDUCED CONTRACTURE OF THE GUINEA PIG TAENIA COLI
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概要
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It was reported that high-potassium (K) solution produced a contracture (K-induced contracture) in the guinea pig taenia coli, and the tension development in the muscle depolarized with high-K was dependent on calcium (1, 2), and that <SUP>45</SUP>Ca uptake and exchangeable fraction of cellular Ca increased with high-K (2). Furthermore, it was demonstrated that K-induced contracture was composed of phasic and tonic phases and was proposed that in the phasic contraction, sufficient calcium was released from a cellular site to initiate contraction, whereas in the tonic contraction, enough calcium crossed the membrane to initiate it and that the transmembrane calcium transport involved in the latter response was dependent on metabolism (3). On the basis of these results, the role of metabolism in the K-induced contracture of taenia coli was examined by the use of various metabolic intermediates, inhibitors of metabolism and active transport, revealing that the factors such as substrate removal, a decrease of temperature, DNP, ouabain and a substitution of external sodium chloride with lithium chloride abolished the tonic response whereas the same factors had little or no effect on the phasic response. Hence it was considered that the phasic response was a passive process, while the tonic contraction was an active one depending on metabolism and possibly linked to active Na transport (4). This consideration was also supported by the electrophysiological experiments (5). In the present paper, further evidence was obtained concerning to the influences of the physiological components in the external media, that is, magnesium chloride (MgCl<SUB>2</SUB>), sodium bicarbonate (NaHCO<SUB>3</SUB>) and sodium phosphate (NaH<SUB>2</SUB>PO<SUB>4</SUB>) on the K-induced tension development of taenia coli.
- 公益社団法人 日本薬理学会の論文
著者
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浦川 紀元
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo
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池田 三義
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo
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唐木 英明
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo
関連論文
- CHANGES IN TENSION, Ca MOVEMENT AND METABOLISM OF GUINEA PIG TAENIA COLI IN VARYING CONCEN-TRATIONS OF EXTERNAL Na AND K
- MECHANICAL RESPONSE OF GUINEA PIG TAENIA COLI IN HIGH-K/Na-DEFICIENT MEDIUM UNDER ANOXIA
- EFFECTS OF EXTERNAL CALCIUM AND SOME METABOLIC INHIBITORS ON BARIUM-INDUCED TENSION CHANGES IN GUINEA PIG TAENIA COLI
- A GANGLION-BLOCKING ACTION OF THE TOXIN ISOLATED FROM JAPANESE IVORY SHELL (BABYLONIA JAPONICA)
- EFFECTS OF OUABAIN AND 2, 4-DINITROPHENOL ON CALCIUM DISTRIBUTION AND EXCHANGE IN GUINEA PIG TAENIA COLI IN HIGH-POTASSIUM SOLUTION
- MOVEMENTS OF CALCIUM DURING TENSION DEVE-LOPMENT INDUCED BY BARIUM AND HIGH-POTASSIUM IN GUINEA PIG TAENIA COLI
- INCREASE IN 45Ca UPTAKE DURING BARIUM-INDUCED CONTRACTURE IN GUINEA PIG TAENIA COLI
- EFFECTS OF FACTORS INHIBITING TENSION DEVELOPMENT ON OXYGEN CONSUMPTION OF GUINEA PIG TAENIA COLI IN HIGH K MEDIUM
- EFFECTS OF CALCIUM DEPLETION ON OXYGEN CONSUMPTION IN GUINEA PIG TAENIA COLI
- OXYGEN CONSUMPTION AND MUSCLE TENSION WITH HIGH POTASSIUM IN GUINEA PIG TAENIA COLI BY SUBSTITUTING STRONTIUM FOR CALCIUM
- CALCIUM DEPLETION ON OXYGEN CONSUMPTION ACCOMPANYING TENSION CHANGE INDUCED BY HIGH POTASSIUM IN GUINEA PIG TAENIA COLI
- EFFECT OF HISTAMINE ON CALCIUM EXCHANGE IN GUINEA PIG TAENIA COLI
- EFFECTS OF OUABAIN AND METABOLIC INHIBITING FACTORS ON Ca DISTRIBUTION DURING K-INDUCED CONTRACTURE IN GUINEA PIG TAENIA COLI
- 45Ca UPTAKE AND TISSUE Ca OF GUINEA PIG TAENIA COLI IN ISOTONIC HIGH-K/Na-DEFICIENT MEDIUM
- EFFECTS OF ANION SUBSTITUTIONS ON POTASSIUM-INDUCED PHASIC AND TONIC CONTRACTION IN TAENIA COLI
- OXYGEN CONSUMPTION DURING POTASSIUM INDUCED CONTRACTURE IN GUINEA PIG TAENIA COLI
- BIOGENIC AMINES AND ACTIVE POLYPEPTIDES IN THE SKIN OF TEN JAPANESE AMPHIBIAN SPECIES
- GANGLION STIMULATING ACTION OF CANDICINE
- INFLUENCES OF EXTERNAL MAGNESIUM, BICARBONATE AND PHOSPHATE ON POTASSIUM-INDUCED CONTRACTURE OF THE GUINEA PIG TAENIA COLI
- EFFECT OF LITHIUM SUBSTITUTION FOR SODIUM ON OXYGEN CONSUMPTION OF GUINEA PIG TAENIA COLI IN HIGH K MEDIUM