COCAINE-LIKE ACTIONS OF HEXYLGUANIDINE

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概要

• 論文の詳細を見る

• Ozawa <I>et al</I>. have reported the effects and the structure-activity relationship of mono-alkylguanidines on the smooth muscle preparations innervated by the sympathetic nerve, on the cardiac activity and on the blood pressure (1). In the paper, they concluded that the actions of monoalkylguanidino compounds were different between the compounds with a small substituent and a bulky substituent, and that the activity increased according to the carbon numbers. These results coincide with the report by Ozawa <I>et al</I>. (2) on the effect and the structure-activity relationship of monoalkylguanidines in the skeletal muscle preparation.<BR> In the present paper, authors investigated in more detail the action of hexylguanidine which has the most bulky carbon chain among these compounds and revealed a most striking pharmacological action resemble to cocaine.

• 社団法人 日本薬理学会の論文

著者

• 菅原 和信

  Department of Pharmacy, Hirosaki University Hospital

• 小澤 光

  Department of Chemical Pharmacology, Tohoku University School of Medicine

• 小澤 光

  Department of Chemical Pharmacology, Pharmaceutical Institute, Tohoku University School of Medicine

• 菅原 和信

  Department of Chemical Pharmacology, Pharmaceutical Institute, Tohoku University School of Medicine

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