EFFECTS OF CHLORPROMAZINE, TETRABENAZINE AND AZACYCLONOL ON BRAIN SEROTONIN LEVEL OF SHOCKED RATS

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Since the presence of serotonin in the brain was first reported by Twarog and Page (1), and Amin, Crawfold and Gaddum (2), serotonin has been approached by many investigators. A number of informations concerning the effects of tranquilizing agents, especially reserpine and its related compounds, on serotonin level in brain have been reported. Brain serotonin is especially associated with reserpine as shown by the evidence that the central actions of reserpine are mediated through serotonin.<BR> In the preceding papers (3, 4), authors reported that the effects of a certain tranquilizing agents on rat brain catecholamine levels in shocked state were investigated, and resulted that some of them, i.e., chlorpromazine, tetrabenazine and azacyclonol showed the effects to inhibit the elevation of catecholamine levels caused by electroshock.<BR> In the present study, the effects of chlorpromazine, tetrabenazine and azacyclonol on rat brain serotonin level in shocked state same conditions as that in the case of catecholamine levels, were investigated.
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