A PHARMACOLOGICAL STUDY OF 6-HYDROXY-4a, 10-TRIMETHYLENE-1, 2, 3, 4, 4a, 9, 10, l0a-OCTAHYDROPHENANTHRIDINE

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概要

• 論文の詳細を見る

• The structure-activity relationship of various chemical compounds, which resembled to morphine in their structures and were synthesized by Sugimoto <I>et al</I>. (1), has been reported. Among those compounds a racemic 6-hydroxy-4a, 10-trimethylene-1, 2, 3, 4, 4a, 9, 10, 10a-octahydrophenanthridine hydrochloride (DH-7), which have a nitrogen atom at 9-position of the morphinan ring, showed almost the same strong analgesic activities as morphine hydrochloride in a series of screening test.<BR> Further studies of the analgesic activity of DH-7 and the comparative pharmacological studies of the drug with morphine hydrochloride and levorphanol tartrate are described in this report. DH-7 has a chemical structure, shown in the following structural formula.

• 公益社団法人 日本薬理学会の論文

著者

• SUGIMOTO NORIO

  Osaka Research Laboratory, Tanabe Seiyaku Co.

• Sugimoto Norio

  Osaka Research Laboratory Tanabe Seiyaku Co., Ltd.

• HAYASHI GORO

  Osaka Research Laboratory, Tanabe Seiyaku Co.

• FUJIMURA HAJIME

  Institute for Chemical Research, Kyoto University

• Fujimura H.

  Institute for Chemical Research, Kyoto University

関連論文

• Studies on Heavy-Nitrogen Labeled Compounds. III. Preparation of 15N-Labeled α-Hydroximinopropionic Acid
• A PHARMACOLOGICAL STUDY OF 6-HYDROXY-4a, 10-TRIMETHYLENE-1, 2, 3, 4, 4a, 9, 10, l0a-OCTAHYDROPHENANTHRIDINE

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