EFFWCT OF DIISOPROPYL 1, 3-DITHIOL-2-YLIDENEMALONATE (NKK-105) ON FATTY LIVER INDUCED BY CARBON TETRACHLORIDE

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概要

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• The therapeutic effect of diisopropyl 1, 3-dithiol-2-ylidene-malonate (NKK-105) on the fatty liver induced by carbon tetrachloride (CCl<SUB>4</SUB>) was studied. The recovery from elevated liver triglyceride levels induced by CCl<SUB>4</SUB> required over 20 days in 35 week-old rats, but 14 days in 6 week-old rats. This indicates that 35 week-old rats are useful for studying the therapeutic effect of NKK-105 on fatty liver. In rats with CCl<SUB>4</SUB>-induced fatty liver, NKK-105 lowered the hepatic triglyceride level, accelerated the rate of triglyceride release from the liver, enhanced the incorporation of <SUP>14</SUP>C-leucine into microsomal protein, and increased the RNA content in microsomes. These data suggest that NKK-105 exerts a curative effect on CCl<SUB>4</SUB>-induced fatty liver by improving the impaired protein synthesis and by promoting lipoprotein secretion.

• 社団法人 日本薬理学会の論文

著者

• Kasai Tsutomu

  Biological Research Center Nihon Nohyaku Co. Ltd.

• Sugimoto Tatsuyoshi

  Biological Research Center Nihon Nohyaku Co. Ltd.

• IMAIZUMI Yohko

  Biological Research Center, Nihon Nohyaku Co., Ltd.

関連論文

• EFFECT OF DIISOPROPYL 1,3-DITHIOL-2-YLIDENEMALONATE ON MICROSOMAL ELECTRON TRANSPORT SYSTEM IN RAT LIVER
• EFFWCT OF DIISOPROPYL 1, 3-DITHIOL-2-YLIDENEMALONATE (NKK-105) ON FATTY LIVER INDUCED BY CARBON TETRACHLORIDE

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