Effect of idebenone (CV-2619) on memory impairment observed in passive avoidance task in rats with cerebral embolization.
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概要
- 論文の詳細を見る
Effect of idebenone (CV-2619) on memory impairment was studied in rats with cerebral embolization. The cerebral embolization, produced by injecting 2000 microspheres into the internal carotid artery, caused a significant impairment in passive avoidance response. Repeated administrations of idebenone (30 mg/kg/day, i.p.), partially but significantly improved the impairment of the passive avoidance response in the embolized rats. The results suggest that the repeated administration of idebenone exerts an ameliorating effect on memory impairment induced by cerebral embolization.
- 公益社団法人 日本薬理学会の論文
著者
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Nagaoka Akinobu
Biological Research Laboratories Takeda Chemical Industries Ltd.
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MIYAMOTO Masaomi
Biology Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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Hamajo Kazuhiro
Biological Research Laboratories, Central Research Division, Takeda Chemical Ind. Ltd.
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KIYOTA Yoshihiro
Biology Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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