Natriuretic action of manidipine hydrochloride, a new calcium channel blocker, in spontaneously hypertensive rats.
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概要
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Effects of manidipine, a new dihydropyridine derivative, on sodium and water excretion were examined in conscious spontaneously hypertensive rats. Manidipine (3 mg/kg) significantly increased the sodium and water excretion in the urine collected for 3 hr after the calcium antagonist was orally administered, and its natriuretic action was more prominent than those of nifedipine and nicardipine (3 mg/kg). These results suggest that manidipine may be useful for treating hypertension.
- 公益社団法人 日本薬理学会の論文
著者
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Nagaoka Akinobu
Biological Research Laboratories Takeda Chemical Industries Ltd.
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NAGAOKA Akinobu
Biology Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
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SHIBOTA Masaki
Biological Research Laboratories, Central Research Division Takeda Chemical Industries
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