Heterogeneity of cross-reactivity of mouse anti-benzylpenicilloyl antibodies against cephalothin haptens or polymers.

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概要

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• The cross-reactivity of mouse anti-benzylpenicilloyl antibodies against cephalothin-haptens and cephalothin-polymers was divergent depending on the source and isotype of antibodies and the methods to raise them. High cross-reactivity nearly equal to the reactivity to homologous haptens and polymers was obtained only with the IgE antibody of C57BL/6J mouse raised shortly after an immunizing injection of the emulsion containing Freund's complete adjuvant and benzylpenicilloyl-bovine γ-globulin conjugate. With the other antibody preparations, cross-reactivity was moderate to negligible.

• 公益社団法人 日本薬理学会の論文

著者

• TAKEUCHI Mitsuo

  Shionogi Research Laboratories, Shionogi & Co., Ltd.

• HARADA Minoru

  Shionogi Research Laboratories, Shionogi & Co., Ltd.

• WATANABE Akira

  Shionogi Research Laboratories, Shionogi & Co., Ltd.

関連論文

• Heterogeneity of cross-reactivity of mouse anti-benzylpenicilloyl antibodies against cephalothin haptens or polymers.
• Cephalothin and penicillin G polymers as elicitors of rat PCA mediated by mouse IgE antibodies.

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