Cephalothin and penicillin G polymers as elicitors of rat PCA mediated by mouse IgE antibodies.

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PCA-eliciting activities of cephalothin and penicillin G-polymers were examined in rats sensitized with homologous IgE antibodies of mouse origin. Cephalothin-polymers elicited PCA regardless of the source of antibodies and the methods to raise them, the minimal effective dose being 2 to 20 μg/animal. Penicillin G-polymers provoked PCA only when anti-benzylpenicilloyl IgE antibody of C57BL/6J mouse raised early after immunization was used. The minimal effective dose in this case was 5 μg/animal, being comparable to that of cephalothin polymers.
公益社団法人日本薬理学会の論文