Effects of quinidine and cimetidine on the methamphetamine level in the rat brain.

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概要

• 論文の詳細を見る

• The drug interaction between methamphetamine and quinidine/ cimetidine was investigated in terms of distribution of methamphetamine to the brain. The concentrations of methamphetamine and amphetamine in the brain after an s.c. Injection of methamphetamine were determined in rats pretreated with a single oral dose of quinidine or cimetidine. Both drugs markedly enhanced the increase in the concentrations of methamphetamine and its metabolite, amphetamine. These results suggest that the recent finding of the enhancements of the behavioral effect of methamphetamine by quinidine and cimetidine is due to the increase in levels of methamphetamine and amphetamine in the brain by these pretreatment drugs.

• 公益社団法人 日本薬理学会の論文

著者

• CHIANG Horng-Jen

  Department of Applied Pharmacology, School of Pharmacy, Hoshi University

関連論文

• STUDIES ON THE MECHANISM OF INTERACTION BETWEEN METHAMPHETAMINE AND QUININE IN RATS
• Effects of quinidine and cimetidine on the methamphetamine level in the rat brain.

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