Suppressive effect of tritoqualine on enzyme leakage induced by D-galactosamine in rat primary-cultured hepatocytes.

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概要

• 論文の詳細を見る

• Tritoqualine (TRQ) was previously reported to suppress enzyme leakage and lipid peroxidation induced by carbon tetrachloride in isolated hepatocytes. In the present study, we investigated the effect of TRQ on enzyme leakage from rat primary-cultured hepatocytes using D-galactosamine (GaIN) which causes hepatic injury without lipid peroxidation. Leakage of GPT and GPT was significantly increased at 18 hr after GaIN addition, being saturated at 42-50 hr. This enzyme leakage was suppressed dose-dependently by TRQ at 42 hr, but not by vitamin E. These results suggest that TRQ shows a suppressive effect on enzyme leakage from hepatocytes independently of its inhibitory action on lipid peroxidation.

• 公益社団法人 日本薬理学会の論文

著者

• Umezu Kohei

  Pharmaceuticals Laboratory Yokohama Research Center Mitsubishi Chemical Corporation

• Yuasa Satoshi

  Pharmaceuticals Laboratory Yokohama Research Center Mitsubishi Chemical Corporation

• YUASA Satoshi

  Pharmaceuticals Laboratory, Research Center, Mitsubishi Chemical Ind., Ltd.

• NAKAO Yoshihide

  Pharmaceuticals Laboratory, Research Center, Mitsubishi Chemical Ind., Ltd.

• UMEZU Kohei

  Pharmaceuticals Laboratory, Research Center, Mitsubishi Chemical Ind., Ltd.

関連論文

• Hepatocyte Growth Factor Stimulates Liver Regeneration and Elevates Blood Protein Level in Normal and Partially Hepatectomized Rats
• Suppressive effect of tritoqualine on enzyme leakage induced by D-galactosamine in rat primary-cultured hepatocytes.
• Effect of tritoqualine on the proliferation of interleukin-3 dependent cell line and sensitive cells.

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