Effect of tritoqualine on the proliferation of interleukin-3 dependent cell line and sensitive cells.

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概要

• 論文の詳細を見る

• In this paper, the effect of tritoqualine (TRQ) on the proliferation of interleukin (IL) sensitive cells was investigated. TRQ inhibited the proliferation of FDCp-2 (IL-3 dependent cell line), CTLL-2 (IL-2 dependent cell line) and bone marrow cells (BMC) stimulated by IL, giving an ID50 of about 3 μM equally in the three systems. However, a ten times higher concentration of TRQ was required to inhibit the tumor cell proliferation. TRQ did not affect the unstimulated bone marrow cells. Accordingly, it is suggested that TRQ may show its anti-allergic effect, at least partially, by interfering with the proliferation/differentiation to mast cell and basophils of multi-functional hemato-poietic cells stimulated by IL-3.

• 公益社団法人 日本薬理学会の論文

著者

• Umezu Kohei

  Pharmaceuticals Laboratory Yokohama Research Center Mitsubishi Chemical Corporation

• OGAWA Tomoko

  Pharmaceuticals Laboratory, Research Center, Mitsubishi Chemical Ind. Ltd.

• UMEZU Kohei

  Pharmaceuticals Laboratory, Research Center, Mitsubishi Chemical Ind. Ltd.

• NAKAGAWA Yoshio

  Pharmaceuticals Laboratory, Research Center, Mitsubishi Chemical Ind. Ltd.

• SATO Shigeru

  Pharmaceuticals Laboratory, Research Center, Mitsubishi Chemical Ind. Ltd.

関連論文

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• Induction of Differentiation of HL-60 Cells by the Anti-fungal Antibiotic, Radicicol
• Suppressive effect of tritoqualine on enzyme leakage induced by D-galactosamine in rat primary-cultured hepatocytes.
• Effect of tritoqualine on the proliferation of interleukin-3 dependent cell line and sensitive cells.

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