Glibenclamide specifically blocks ATP-sensitive K+ channel current in atrial myocytes of guinea pig heart.

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概要

• 論文の詳細を見る

• Effects of glibenclamide on the control membrane ionic currents, acetylcholine or adenosine-induced K<SUP>+</SUP> current, and nicorandil-induced K<SUP>+</SUP> current were examined in single atrial myocytes of guinea pig heart. The nystatin-whole cell clamp technique was used. Nicorandil evoked the time-independent K<SUP>+</SUP> current which is probably the current through the ATP-sensitive K<SUP>+</SUP> channel. Glibenclamide inhibited this current in a concentration-dependent fashion, although it had no effect on the other currents. We concluded that glibenclamide specifically inhibits the ATP-sensitive K<SUP>+</SUP> channel current in cardiac myocytes.

• 公益社団法人 日本薬理学会の論文

著者

• Kurachi Yoshihisa

  The Second Department of Internal Medicine Faculty of Medicine, University of Tokyo

• Takikawa Reiko

  The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• ITO Hiroyuki

  The Second Department of Internal Medicine, Kochi Medical School

• Sugimoto Tsuneaki

  The Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• KURACHI Yoshihisa

  The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Terano Akira

  The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• HAMADA Eiji

  The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• IGUCHI Mari

  The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• ITO Hiroyuki

  The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

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