Effects of intracerebroventricular administration of magnesium sulphate on blood pressure and heart rate in anesthetized normotensive and hypertensive rats.

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概要

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• Intracerebrove ntricuIar (i.c.v.) injection of magnesium sulphate (MgSO<SUB>4</SUB>: 2.5, 5 and 10 μmol in 5 μl) decreased blood pressure and heart rate in both anesthetized normotensive (WKY) and hypertensive rats (SHR). The effects were greater in WKY than in SHR. Moreover, a pretreatment with hexamethonium (2 mg/kg, i.v.) significantly blunted the hypotensive and bradycardic effects induced by i.c.v. injection of 10 μmol of MgSO<SUB>4</SUB> in both WKY and SHR. Our data suggest that MgSO<SUB>4</SUB> produces hypotensive and bradycardic effects when injected i.c.v. in both WKY and SHR.

• 公益社団法人 日本薬理学会の論文

著者

• STURNIOLO Rosa

  Institutes of Pharmacology, Medical School, University of Messina

• SQUADRITO Francesco

  Institutes of Pharmacology, Medical School, University of Messina

• BUEMI Anna

  Institutes of Pharmacology, Medical School, University of Messina

• BUEMI Michele

  Internal Medicine, Medical School, University of Messina

• CORICA Francesco

  Internal Medicine, Medical School, University of Messina

• FRISINA Nicola

  Internal Medicine, Medical School, University of Messina

• SQUADRITO Giuseppe

  Internal Medicine, Medical School, University of Messina

• CAPUTI Achille

  Institutes of Pharmacology, Medical School, University of Messina

関連論文

• Effects of intracerebroventricular administration of magnesium sulphate on blood pressure and heart rate in anesthetized normotensive and hypertensive rats.
• Central dipsogenic effect of synthetic rat atrial natriuretic polypeptide in normotensive rats.

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