Central dipsogenic effect of synthetic rat atrial natriuretic polypeptide in normotensive rats.

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概要

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• The effect of intracerebroventricular (i.c.v.) injection of synthetic rat atrial natriuretic polypeptide (α-rANP) on drinking behavior was studied in normotensive rats, α-rANP (0.2, 0.4 or 0.8 μg in 5 μl) caused a dose-dependent dipsogenic effect which was abated by i.c.v. pretreatment with saralasine (9 μg in 5 μl). These results suggest that α-rANP possesses dipsogenic effects in water repleted rats and that brain angiotensin is involved. In addition, our data indicate that, at least as far as the effect of cerebral ANP is concerned, there are some differences between α-rANP and human atrial natriuretic polypeptide.

• 公益社団法人 日本薬理学会の論文

著者

• SQUADRITO Francesco

  Institutes of Pharmacology, Medical School, University of Messina

• BUEMI Michele

  Internal Medicine, Medical School, University of Messina

• FRISINA Nicola

  Internal Medicine, Medical School, University of Messina

• SQUADRITO Giuseppe

  Internal Medicine, Medical School, University of Messina

• CAPUTI Achille

  Institutes of Pharmacology, Medical School, University of Messina

• SANTORO Giuseppe

  Institutes of Pharmacology, Medical School, University of Messina

• CALAPAI Gioacchino

  Institutes of Pharmacology, Medical School, University of Messina

• AUTOLITANO Aldo

  Institutes of Pharmacology, Medical School, University of Messina

関連論文

• Effects of intracerebroventricular administration of magnesium sulphate on blood pressure and heart rate in anesthetized normotensive and hypertensive rats.
• Central dipsogenic effect of synthetic rat atrial natriuretic polypeptide in normotensive rats.

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