Inhibitory effects of OKY-046 on spasmogen-induced bronchoconstrictions in sensitized and non-sensitized guinea pigs.
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概要
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We examined the effect of thromboxane A<SUB>2</SUB>(TXA<SUB>2</SUB>) synthetase inhibitor, OKY-046, on bronchoconstriction induced by antigen and various spasmogenic mediators in guinea pigs in vivo. Further, inhibitory activities of OKY-046 on contractions of isolated tracheae and lung parenchymal strips induced by various contractile agents were also investigated in vitro. OKY-046, but not indomethacin, significantly inhibited antigen-induced bronchoconstriction in a dose-dependent manner. Moreover, OKY-046 attenuated bronchoconstrictions induced by peptide leukotrienes (LTs) and platelet activating factor (PAF), but not those by histamine, prostaglandin D<SUB>2</SUB> (PGD<SUB>2</SUB>) and STA<SUB>2</SUB> (a stable TXA<SUB>2</SUB> mimetic agent). Although contractile responses induced by spasmogens such as peptide LTs, PAF and histamine were not influenced by OKY-046 in isolated tracheae, OKY-046 elicited significant and concentration-dependent inhibitions against contractile responses induced by peptide LTs and PAF in isolated lung parenchymal strips. These results suggest the possible involvement of TXA<SUB>2</SUB> in the development of anaphylactic bronchoconstriction in sensitized guinea pigs.
- 公益社団法人 日本薬理学会の論文
著者
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Okegawa Tadao
Minase Research Institute, Ono Pharmaceutical Co., Ltd.
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Kawasaki Akiyoshi
Minase Research Institute, Ono Pharmaceutical Co., Ltd.
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Nambu Fumio
Minase Research Institute, Ono Pharmaceutical Co., Ltd.
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Motoishi Mariko
Minase Research Institute, Ono Pharmaceutical Co., Ltd.
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IKEDA Shigeru
Central Research Laboratories, Research Institute, Kissei Pharmaceutical Co., Ltd.
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IKEDA Shigeru
Central Research Laboratories, Kissei Pharmaceutical Cc., Ltd.
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OMAWARI Nagashige
Minase Research Institute, Ono Pharmaceutical Co., Ltd.
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