Effects of diltiazem on plasma uric acid level and renal uric acid excretion in rats.
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概要
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The effects of diltiazem on plasma uric acid level (P<SUB>UA</SUB>) and renal uric acid excretion were investigated in oxonate-loaded rats. Diltiazem (0.5 mg/kg, i.v.) decreased P<SUB>UA</SUB> without producing uricosuria, and it decreased fractional excretion of uric acid and renal blood flow. The present results suggest that diltiazem produces hypouricemia not accompanied by uricosuria, probably by affecting uric acid metabolism, and it may also cause an alteration in the renal handling of uric acid partly due to changes in renal hemodynamics.
- 公益社団法人 日本薬理学会の論文
著者
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Shimada Hideyo
Department Of Clin Ical Pharmacology School Of Pharmaceutical Sciences Kitasato University
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SUGINO Haruko
Department of Clinical Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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Sugino Haruko
Department Of Clin Ical Pharmacology School Of Pharmaceutical Sciences Kitasato University
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