Intravenous Infusion of Diltiazem Causes Uricosuria with Concomitant Hypouricemia in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The effects of the continuous intravenous infusion of diltiazem on plasma urate levels and the urinary excretion of urate were examined in urethane anesthetized oxonate-loaded rats. The intravenous infusion of diltiazem (4 or 10 μg/rat/min) caused a gradual decrease in blood pressure, a gradual increase in renal blood flow and a transient increase in glomerular filtration rate. This infusion also caused diuresis, natriuresis, uricosuria and definite hypouricemia. Our results show that diltiazem infused i.v. has uricosuric and hypouricemic effects.
- 公益社団法人日本薬学会の論文
- 1996-04-15
著者
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SHIMADA Hideyo
Department of Internal Medicine , Keio University
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Shimada Hideyo
Department Of Clin Ical Pharmacology School Of Pharmaceutical Sciences Kitasato University
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SUGINO Haruko
Department of Clinical Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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Sugino Haruko
北里大学薬学部附属臨床薬学研究センター
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Sugino Haruko
Department Of Clin Ical Pharmacology School Of Pharmaceutical Sciences Kitasato University
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