Effects of OKY-046, a selective thromboxane A2 synthetase inhibitor, on ventricular arrhythmias and prostaglandins during coronary artery ligation and reperfusion in anesthetized dogs.
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概要
- 論文の詳細を見る
Effects of OKY-046, a selective thromboxane synthetase inhibitor, on ischemia-induced ventricular arrhythmias were investigated in anesthetized dogs. OKY-046 (30 mg/kg, intravenously) decreased ventricular arrhythmias significantly both during 30 min of coronary artery ligation and subsequent reperfusion, which corresponded with a significant reduction of thromboxane concentration, suggesting that thromboxane released during ligation is an important factor in the development of ventricular arrhythmias. Inhibition of thromboxane synthesis with OKY-046 might be useful for the prevention of ischemia-induced ventricular arrhythmias.
- 公益社団法人 日本薬理学会の論文
著者
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Ozawa Yukio
2nd Department of Internal Medicine, Nihon University School of Medicine
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Saito Satoshi
2nd Department of Internal Medicine, Nihon University School of Medicine
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Saito Tomoaki
2nd Department of Internal Medicine, Nihon University School of Medicine
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Ogura Toshitsugu
2nd Department Of Internal Medicine, Nihon University School Of Medicine
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Watanabe Ichiro
2nd Department Of Internal Medicine School Of Medicine Nihon University
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HATANO Michinobu
2nd Department of Internal Medicine, Nihon University School of Medicine
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