ANTI-ANAPHYLACTIC ACTIVITIES OF A NEW BENZOPYRANOPYRIDINE DERIVATIVE Y-12, 141 IN RATS AND GUINEA PIGS
スポンサーリンク
概要
- 論文の詳細を見る
The active anaphylactic bronchoconstriction of rats mediated by IgE-like antibody against DNP-Ascaris was inhibited by intravenous and intratracheal treatment with Y-12, 141 in a dose-dependent manner. In both routes, the inhibitory effect of Y-12, 141 on this response was more potent than that of disodium cromoglycate (DSCG). The oral administration of Y-12, 141 also produced a similar inhibition of the response. The passive anaphylactic bronchoconstriction of guinea pigs mediated by IgG-like antibody against egg albumin was also prevented dose-dependently by treatment with Y-12, 141 given intravenously, but not with DSCG. The present results suggest that Y-12, 141 may be effective for the treatment of allergic bronchial asthma.
- 社団法人 日本薬理学会の論文
著者
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Maruyama Yutaka
Research Laboratories Yoshitomi Pharmacoceutical Industries Ltd.
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Terasawa Michio
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd
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GOTO KAZUHIRO
Research Laboratories, Yoshitomi Pharmaceutical Industries Ltd.
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KADOBE Yukinobu
Research Laboratories, Yoshitomi Pharmaceutical Industries Ltd.
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TERASAWA MICHIO
Research Laboratories, Yoshitomi Pharmaceutical Industries Ltd.
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