Effect of Y-24180, a Platelet-Activating Factor-Receptor Antagonist, on the Antigen-Induced Airway Microvascular Leakage in Guinea Pigs
スポンサーリンク
概要
- 論文の詳細を見る
The inhibitory effect of Y-24180 ((±)-4-(2-chlorophenyl)-2-[2-(4-isobutylphenyl)ethyl]-6, 9-dimethyl-6<I>H</I>-thieno[3, 2-<I>f</I>][1, 2, 4]triazolo[4, 3-a][1, 4]diazepine) on platelet-activating factor (PAF)- or antigen-induced airway microvascular leakage was studied in guinea pigs by oral administration. The tissue content of extravasated Evans blue dye was used as an index of plasma exudation in the trachea, main bronchi, central intrapulmonary airways and peripheral intrapulmonary airways. In all of these tissues. Y-24180 potently inhibited the leakage induced by PAF. The ED<SUB>50</SUB> Value of Y-24180 determined in each of the tissues was approximately 0.02 mg/kg, demonstrating that the inhibitory potency of Y-24180 is 4-6 times that of WEB 2086, another PAF antagonist. Even at a dose of 10 mg/kg, however, Y-24180 showed no inhibitory effect on the leakage induced by leukotriene (LT) D<SUB>4</SUB>, histamine or bradykinin. In the antigeninduced model of guinea pigs sensitized with aerosolized ovalbumin, Y-24180 (0.1-10 mg/kg) and WEB 2086 (1-100 mg/kg) potently inhibited the microvascular leakage in all of the examined airway tissues except for the trachea. At 1-100 mg/kg, however, both ON0-1078, an LT-receptor antagonist, and OKY-046, a thromboxane A<SUB>2</SUB> synthetase inhibitor, prevented partially but not significantly the antigen-induced leakage. These results provide evidence that endogenous PAF partially mediates the antigen-induced airway microvascular leakage in guinea pigs.
- 社団法人 日本薬理学会の論文
- 1996-11-01
著者
-
Yamaguchi S
Tsurumi Univ. Yokohama Jpn
-
Yamaguchi Shuji
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd
-
KAGOSHIMA Masahiko
Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd
-
TERASAWA Michio
Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd
-
Terasawa Michio
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd
-
IWAHISA Yoshinori
Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd.
-
Iwahisa Yoshinori
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
-
Kagoshima Masahiko
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd
関連論文
- B31 DETECTION OF HEPATOCARCINOGENIC POTENTIAL OF 5 CHEMICALS BY A MEDIUM-TERM BIOASSAY SYSTEM
- Modifying Influence of Swine Serum-induced Liver Fibrosis on Development of Preneoplastic Lesions in Rat Liver
- Suppressive Effects of Y-24180, a Long-Acting Antagonist for Platelet-Activating Factor, on Allergic Pulmonary Eosinophilia in Mice
- IMMUNOPHARMACOLOGICAL PROPERTIES OF NEW ANTIALLERGIC AGENT Y-12,141
- Effect of Y-24180, a Platelet-Activating Factor-Receptor Antagonist, on the Antigen-Induced Airway Microvascular Leakage in Guinea Pigs
- ANTI-ANAPHYLACTIC ACTIVITIES OF A NEW BENZOPYRANOPYRIDINE DERIVATIVE Y-12, 141 IN RATS AND GUINEA PIGS
- TRAXANOX AUGMENTS IMMUNE RESPONSE TO LIPOPOLYSACCHARIDE IN INBRED MICE: ROLE OF MACROPHAGES
- Stimulation of phagocytic activity of leukocytes and macrophages by traxanox sodium in mice and rats.
- Effect of cysteine ethylester hydrochloride (CystaninR) on host defense mechanisms. (IV). Potentiating effects on the function of peritoneal or spleen macrophages.
- An antagonistic activity of etizolam on platelet-activating factor(PAF). In vitro effects on platelet aggregation and PAF receptor binding.
- Effect of etizolam (Depas) on production of superoxide anion by platelet-activating factor and N-formyl-methionyl-leucyl-phenylalanine-stimulated guinea pig polymorphonuclear leukocytes.
- Effect of cysteine ethylester hydrochloride (Cystanin) on host defense mechanisms (V): Potentiation of nitroblue tetrazolium reduction and chemiluminescence in macrophages or leukocytes of mice or rats.