Protease-antiproteaseの観点よりみた扁桃炎の研究 : 第2報 ヒト扁桃組織の線溶系関与物質に関する研究
スポンサーリンク
概要
- 論文の詳細を見る
We have already reported that the enhancement of fibrinolytic activity in blood has been observed in the patients suffering acute tonsillitis. From this result, it was suggested trigger substance which caused the enhancement of fibrinolytic activity might be released from that a tonsillar tissue. Furthermore, it was thought that fibrinolytic activity might give important effects to inflammatory process of tonsil. In order to clarify these questions substances in tonsillar tissue relating to fibrinolysis were studied by means of biochemical procedures. Physicochemical properties of these substances, and the localization about these substances in tonsillar tissue cells were also studied. Materials were obtained from human tonsillar tissues with chronic tonsillitis and hypertrophied tonsils. In order to study the localization of the substances in the cells, rat liver were also used. The results obtained from this experiment were as follows: 1) In saline extraction of tonsillar tissue homogenates, anti-urokinase activity was observed. 2) In phosphate-buffer extraction of acetone powder of the tonsillar tissue, tissue plasmin-ogen activator activity was observed. 3) By gel filtration (G-200) of anti-urokinase, it was observed that the inhibitory activity to urokinase was stronger in the eluates of large molecular portion than in those of low moles ular portion. 4) By gel filtration (G-50) of tissue plasminogen activator, it was observed that the activ-ator was eluated at the void volume portion. 5) In lysosome rich fraction of the tonsillar tissue, anti-urokinase activity was observed, but tissue plasminogen activator did neither exit in tonsillar tissue cells nos in rat liver cells.
- 社団法人 日本耳鼻咽喉科学会の論文
著者
関連論文
- Protease-antiproteaseの観点よりみた扁桃炎の研究 : 第4報 扁桃摘出術の後出血における血中線溶活性の意義
- Protease-antiproteaseの観点よりみた扁桃炎の研究 : 第2報 ヒト扁桃組織の線溶系関与物質に関する研究
- Protease-antiproteaseの観点よりみた扁桃炎の研究 : 第1報 ヒト急性扁桃炎の血中線溶に関する研究