大切片組織標本による前庭部喉頭癌の病理学的研究

概要

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Extent of infiltration was investigated by macro- and microscopic observations in 41 specimens of laryngeal cancers which were removed by the partial or total laryngectomy.The following results were obtained:1) In 41% of the specimens, cancers were found in the larngeal vestibule. In this region, laryngeal cancers was thought to develope from the metaplastic epithelium.2) Cancers in laryngeal vestibule had a tendency to infiltrate into the preepiglottic space. The extent of this infiltration corresponded with the degree of retroflexion of the epiglottis and the extent of cervical lymphonodes metastasis. The decrease of mobility and the strong retroflexion of the epiglottis were thought to be important clinical signs in the anterior infiltration of this cancer.3) The tumor, which infiltrated into the anterior commissure, showed inferior infiltration on perichondrium of the thyroid cartilage. However, infiltration in the mucous membrane of the larynx was not detected.4) Pre-operative irradiation was effective to decrease the number of living tumor cells, but it was not effective to decrease the extent of infiltration.
社団法人日本耳鼻咽喉科学会の論文