実験的中耳真珠腫と骨破壊

スポンサーリンク

概要

• 論文の詳細を見る

• We carried out a series of experiments on rats to study factors involved in the pathogenesis of cholesteatoma, and in the determination and measurement of bone resorption. Skin and in-flammatory agents such as carrageenan and epithelial debris were applied to the middle ear in various combination to induce growing epidermal sacs or cyst and bone resorption, and followed for one to four months.In the first of three groups in which canal skin explants were placed on the denude cochlea, the cyst rate was thirty-six percent in 25 animals without carrageenan on flap and forty-six percent in 22 animals with carrageenan on flap, being the highest incidence in these experiments. The second group having epithelial debris placed on the medial side of the tympanic membrane revealed no cyst in 12 animals without skin flap and thirty-two percent cyst rate in 22 animals with skin flap in the middle ear cavity. In the third group having skin flap in the rat with spontaneously occurred otitis media the cyst rate was forty-four percent in nine animals. The development of epidermal cyst was found to be in the highest incidence at four months after implants. These experiments showed that the epidermal cyst showing growth can be produced experimentally and either a source of epithelium or persistent and repeated inflammatory stimulus is necessary for progression of cyst growth.The determination and measurement of bone resorption were considered second. Among 86 animals, the bone resorption as demonstrated by cochlear fistula, occurred in 11 animals, in which 6 animals were found to have cholesteatoma (cyst rate 54%). Bone resorption withoutcochlea fistula seen in 35 animals was accompanied by development of epidermal cyst in 17 animals (cyst rate 48%), whereas 30 animals without bone resorption brought out 7 cysts (cyst rate 23%). Cochlear defect occurred in 6 of 30 animals with epidermal sacs and in 5 of 55 animals without epidermal sac. These fistula had a thin layer of nflammatory connective tissue over the bony defect. The significance and validity of PG E2 on the connective tissue, which was accomplished by radioimmunoassay, were determined to severity of bone resorption. These experiments showed that the presence of epidermal sac increased the likelihood of bone resorption through the effect of PG E2.

著者

• 白幡 雄一

  東京慈恵会医科大学耳鼻咽喉科学教室

• アブラムソン マクスエル

  コロンビア大学医学部耳鼻咽喉科学教室

関連論文

• 真珠腫性中耳炎の骨破壊 : 第一報組織学的検討より
• 実験的中耳真珠腫と骨破壊
• 各種肉芽の骨破壊に対する影響
• 放射線照射後に生じた顎軟骨肉腫の1例
• 咽喉頭異常感症--当教室〔東京慈恵会医科大学耳鼻咽喉科学教室〕30年の歩みを中心に(臨床ノ-ト)

スポンサーリンク