内リンパ嚢閉鎖および内リンパ嚢吸引によるAP, SP, CMの変化

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The changes of AP, SP and CM were investigated in accordance with the grade of endolymphatic hydrops which was produced by endolymphatic sac obliteration in the guinea pigs. Also, AP, SP and CM were measured in animals in which the endolymphatic sac was suctioned. The results obtained were as follows:1. In animals with a minimum endolymphatic hydrops, a super-normal AP and CM responses were obtained in a few eases.2. With the increase of endolymphatic hydrops, CMs were reduced, where as APs at intensive stimulation were relatively well preserved.3. With the increase of endolymphatic hydrops, the potentials of positive SP were reduced, and a few cases showed the potential change to be a negative SP.4. With the increase of endolymphatic hydrops, the AP latency was increased.5. In endolymphatic sac suction, AP and CM responses at intensive stimulation were well preserved. A slight endolymphatic hydrops was observed. The potential of positive SP was reduced, and a few cases showed the change to cause a negative SP.6. In this series of experiments, the degeneration of the organ of Corti was hardly seen under the light microscope. It is suggested that polarity of positive SP observed in control was influenced to deflect towards negative SP by the increase of endolymphatic hydrops and the change of the biochemical component of the inner ear fluids.