ラット前庭神経核ニューロンの電気生理学的研究(第二報)傾斜刺激に対する反応と半規管からの入力の収束

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It is already known that some single vestibular nuclei unit of the rabbit and cat respond both to the rotational and tilt stimuli.In this experiment the convergence of ampullar and macular impulses on the vestibular nuclei unit was examined by the horizontal rotation and the head tilt in the rat.Experimental animals, surgical preparations and recording procedures were identical with those in the previous report.Rotational stimulus method and unitary response to the rotation were also described there in detail.For the tilt stimulation, the head of animals was manually inclined 10-20 in the roll and pitch planes together with a stereotaxic frame.Seventy-four units out of 167 neurons responded to the tilt stimulation.Neural response patterns to the head tilt in the rat were similar with those observed in the cat.Firing frequency decreased with side-up(i.e.recording side was raised) and increased with side-down in 36 units (Type a).Thirty-one units had opposite trend(Type j).The other 7 units exhibited only the increase or decrease of discharge rate in the inclination to one or both sides.Ninety-seven percent of el-neuron responded to the rotation as well as the head tilt, but in cc-neuron only 64% responded to the rotation.Different rates of the convergent input from the canal in each neuron were statistically significant and possible physiological meaning of this difference was discussed.Out of 153 neurons, which responded to the rotation, 60 units(39.2%) responded to the tilt stimulation and considered to receive the convergent impulses from macular receptors.High degree of the canalotolith convergence observed in the rat was in good parallel with the result in the cat.The convergence in vestibular nucleus is supposed to have the important roles not only in ocular movemet but also in efferent influences upon ampullar receptors, which probably occur in each other.Anatomical locations of the recording sites revealed that most neurons(75.6%) were located in the medial vestibular nucleus, and others in the superitar, lateral and inferior nuclei.Few units existed in the reticular formation and cerebellum.These findings were compared with the morphological studies concerning the termination of the primary vestibular fibers in the cat and monkey
社団法人日本耳鼻咽喉科学会の論文

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久保武
大阪大学医学部耳鼻咽喉科

ラット前庭神経核ニューロンの電気生理学的研究(第二報)傾斜刺激に対する反応と半規管からの入力の収束

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