ラット前庭神経核ニューロンの電気生理学的研究(第一報) : 振子様回転に対する反応について

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Vestibular neuronal response to pendular rotation was examined over the frequency range of 0.15-0.35 Hz and the amplitude of 110- Neuronal activity was picked up by a glass microelectrode filled with lithium carmine solution, amplified by a conventional circuit and displayed on an oscilloscope. Firing frepuencies through an analogue counter were recorded by a pen recorder. Response pattern was computed by the on-line computer and stimulus-frequency curve was photographed on a polaroid film from an oscilloscope display.During the rotation, cellular firing waxed and waned around the resting level in an approximately sinusoidal manner. Response patern was either all-round or threshold cut-off depending on the strength of the angular acceleration and the rate of the resting discharge.The firing frequency of most vestibular neurons (112 out of 126 neurons) tended to be in phase with angular velocity (phase lag re angular acceleration was about 90-). Whereas, that of 14 neurons was corresponded to angular acceleration rather than the velocity (phase lag was almost 0-). Physiological meanings of wide ranged phase lag of rat vestibular neuron were discussed referring to the studies of the cat and monkey. Then the frequeacy range of 0.15-0.35 Hz was presumed to be the transitional frequency range from angular acceleration to velocity. It was, therefore, inferred that the resonant frequency of rat horizontal canal was higher than 0.35 Hz.Directionality of the cellular firing was examined in 115 units, of which 59 were type I (e.g. cells on left side excited by left-going velocity), 53 were type II (reversed type with type I neuron), 2 were type III (cells excited by bidirectional rotation) and 1 belonged to type IV (cells inhibited during rotation). From the finding that type III and IV neurons were probably related to reticular formation, these neurons were assumed to take part in producing such reactions as vertigo, nausea and paleness etc. during rotation
社団法人日本耳鼻咽喉科学会の論文

ラット前庭神経核ニューロンの電気生理学的研究(第一報) : 振子様回転に対する反応について

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