カナマィシン内耳侵入路に関する実験的考察

概要

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The guinea pigs were perfused with tetrazolium reagents for succinic dehydrogenase through the circulatory system. After finishing the perfusion, the organ and tissue were dissected and examined under a microscope. Two organs have revealed us the marked formazan formation within them, one was the kidney in which the proximal tubules were the main site of coloration, another the cochlea in which the stria vascularis, the plexus cochlearis, and the round window were the site of distinct coloration.The proximal tubule of the kidney is known to be the most easily damaged after kanamycin.The drug is also known to have a toxic effect on the cochlea. According to the available literature, the drug accumlates mainly within both the kidney and the inner ear fluids.The author is inclined to think that the site of formazan formation would indicate the site of entrance of kanamycin into the organ from the circulatory system. Therefore, the drug may be supposed to reach the inner ear through the stria vascularis, the plexus cochlearis and the round window.
社団法人日本耳鼻咽喉科学会の論文