Manetolに関する基礎的研究(第1報)

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概要

• 論文の詳細を見る

• Manetol is a kind of hemostyptica which the Bayer Co. in Germany has been successful in extracting from the spinal cord of animals. It has already been made clear that the main ingredient of Manetol is Organ-Thromboplastin, but its effective ingredient as well as its proper quantity to prove effective for a man has nbt yet been brought before the public.So we have made some basic researches in regard to the said point which are considered to be necessary for any clinical operations. The essential point of our researches has been based on a standard of clotting effect that Manetol has, and the followings are the summarizations.(1) Manetol urges blood clotting in case of being used both by means of intravenous injection and of direct effeet upon blood plasma. In these circumstances, Manetol should, to make it most effective, be diluted to some extent. By our researches the most effective standard of consistency of the said fluid is, experimentally, from 10% to 20% or thereabouts. The dilution of this kind proves most effective to cause blood clotting.(2) In case of being used with a rabbit through an intravenous injection, 0.2cc of the said fluid is the proper quantity to urge blood clotting most effectively.(3) Inferring from the proper quantity of injection against a rabbit, an injection of 6 or 7cc may be considered to be most effective for a man of full age to cause clotting.(4) If Manetol is to be injected before any surgical operations, blood seems hard to run out of a cut incised for an operation. The reason of this fact may be considered that besides Thromboplastin of Manetol, tissue Thromboplastinogen contained in the tissue fluid of the cut, is usually activated by an operation making the tissue fluid urge blood to clot, still more Manetol in blood plays a greater part of helping this tendency.(5) On analysing Manetol fluid, through paper chromatography, into some ten kinds of amino acid, considered as main constituent of the said fluid there to be found two or three kinds of them working more actively toward clotting than the others. In case we have an opportunity to obtain pure amino acid, the conclusion will be brought out more in detail.(6) As a result of our various experiments of Manetol both on men and on animals, the side effect has not been acknowledged at all.

• 社団法人 日本耳鼻咽喉科学会の論文

著者

• 白岩 俊雄

  東京医科大学耳鼻咽喉科教室

• 宝迫 慎一郎

  東京医科大学耳鼻咽喉科教室

• 川村 一枝

  東京医科大学耳鼻咽喉科教室

• 斎藤 光憲

  東京医科大学耳鼻咽喉科教室

• 田村 伝

  東京医科大学耳鼻咽喉科教室

• 高橋 晃一

  東京医科大学耳鼻咽喉科教室

• 宝迫 慎一郎

  東京医科大学耳鼻咽喉科学教室

• 白岩 俊雄

  東京医科大学耳鼻咽喉科学教室

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