Manetol に関する基礎的研究 : 第II報感作原性について

概要

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Antigenicity of Manetol was studied using guinea pigs and rabbits. The experiment did not demonstrated any possible side effects due to prolonged administration of Manetol.1. Guinea pigs were sensitized by the intracutaneous or intraperitoneal injection of Manetol alone or Manetol with horse serum. Rabbits were sensitized by the intramuscular injection into the gluteal muscles or intravenous administration. No allergic skin reaction was observed in these animals. In sensitized guinea pigs, no allergic bowel reaction was recongnized. In sensitized rabbits, anaphylactic shock was not observed. Post mortem examination of the animals did not reveal any anaphylactic reactions.2. Anaphylactic antibody against Manetol was not demonstrated in the serum of the sensitized rabbits. The serum of the sensitized guinea pigs did not show precipitation reaction.3. In observation of signs and symptoms, skin test and changes in leucocyte count following to the provocation injection, no difference between the two groups of rabbits which were sensitized either by intramuscular administration or intravenous administration of Manetol was noted.4. Beside the above experiments, hemostatic effect of Manetol on human subject was observed under the capillary microscope.
社団法人日本耳鼻咽喉科学会の論文