Toxicological study of DTPA as a Drug. (IV). Effect of intravenously injected DTPA on cardiovascular system in beagle dogs.:Effect of Intravenously Injected DTPA on Cardiovascular System in Beagle Dogs

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We have previously reported that the side effects on cardiovascular system such as the heart failure, increases of blood pressure and pulse accompanied with hypocalcemia occurred in rats when Zn-DTPA was injected intravenously, but those did not occur by Ca-DTPA. This is in the reverse that it is generally said that Zn-DTPA is more safe than Ca-DTPA. This study was carried out to examine whether the same side effects occurred in different animal species or not. Zn-DTPA or Ca-DTPA (30, 150, 300 and 600μmol/kg) was injected intravenously to beagle dogs. The hypocalcemia was observed in the dogs by Zn-DTPA injection, but it was not by Ca-DTPA. After Zn-DTPA injection, the increase of blood pressure and pulse, and heart failure was observed in 3 out of 5 dogs at 300μmol/kg dose, and in 3 out of 8 dogs at 600μmol/kg dose. These changes were the same degrees as those in rats. In the present study, it is suggested that the side effects induced by Zn-DTPA intravenous injection occur independently of animal species and the data obtained from animal experiments can be available to estimate DTPA toxicity in humans.
日本保健物理学会の論文