タンパク質の結晶成長機構

概要

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The growth of hen egg-white lysozyme crystals over 28 days is followed by photographs, together with the accompanying concentration decrease in the supernatant. The concentration change is shown to be approximated by a theoretical curve derived from a set of simple differential equations. The concentration reaches a constant value after a few months, which is the solubility of the crystals. The solubility changes greatly with temperature, which reflects the enthalpy change upon crystallization. The length (L) and width (W) of a tetragonal crystal are also measured as a function of time. The change in L was greater than that of W, thus explaining the cause of the variation of the crystal morphology. These results, <I>i.e.</I> the kinetic equations, solubility diagrams, and morphogenesis, are examples of the rules underlying the growth of protein crystals.
日本結晶学会の論文