Study of Tumor-Associated Carbohydrate Antigens in Colonic Cancers. Immunohistochemical Analysis by Monoclonal Antibodies.:Immunohistochemical Analysis by Monoclonal Antibodies

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Using several kinds of monoclonal antibodies ( MoAB ) which recognize different carbohydrate antigens, the relations of the normal colonic mucosa, adenoma of the colon, villous adenoma of the colon, early colonic cancer and advanced colonic cancer between the two staining methods were studied. Consequently, staining with MoAB-FH4, AH6 and FH6 was not seen in normal tissues, but slight staining with MoAB-SH1, and TKH2 was noticed. Staining with MoAB-S H1, , MoAB-FH4 and AH6 was noticed in advanced cancer area but not early colonic cancer. But in the cases of MoAB TKH2 there was no difference between early and advanced cancers. Stainability of MoAB-FH6 tends to diminish according to cancer advancement. The patterns made by immunohistological staining with MoAB were mosaic even where the Hematoxylin and eosin staining presented the same histologic form. These results lead to the assumption that cancer, having an isogenic carbohydrate structure at the initial stage when carcinoma in situ is generated, gains heterogeneity as if grows, differentiating into various directions and thus changing into a complicated carbohydrate structure.
日本大腸肛門病学会の論文