Clinical Study on Operative Indications for Crohn's Disease Viewed from Quality of Life and Morphological Findings.

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We compared the pre-operative quality of life in patients with Crohn's disease who eventually underwent surgery (17cases) with patients who did not undergo surgery over average follow-up period of more than 3 years (19 cases). And we also studied on operative indications for Crohn's disease viewed from morphological findings. (1) In the operated cases, the average period from onset of disease to the first operations was 4.8 years. In 88% of cases, the reasons for the first operations were intestinal stenosis and internal fistula. (2)In clinical course, quality of life for the operated cases was clearly unfavorable compared to those who did not underwent surgical treatment. The average score of CDAI at admission and mean duration of admission in operated cases were relatively higher and longer than those of non-operated cases. (3)Viewed from morphological findings by radiographic examinations, there were many cases in which cobblestone appearance and intestinal stenosis with fissuring ulcers developed into intestinal stenosis and internal fistula. In such cases, it was suggested that surgical treatments would be frequently required in furture. The patients with intestinal stenosis over 3 cm in length were frequently induced obstructive symptoms. (4)Early operation was necessary for patients, whose life ability was reduced over average follow-up period of more than 30% by Crohn's disease and its complications. In such cases, morphological complication (such as intestinal stenosis and internal fistula) was also frequently observed.
日本大腸肛門病学会の論文

Clinical Study on Operative Indications for Crohn's Disease Viewed from Quality of Life and Morphological Findings.

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