Significance of CEA Levels Determination in Gallbladder Bile Obtained from Patients with Colorectal Cancer.

概要

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CEA levels in gallbladder (GB) bile obtained from 64 patients with colorectal cancer were determined so that the diagnostic value of them can be evaluated. The levels were significantly high in the patients with liver metastases as compared to those involved no liver lesion (H<SUB>0</SUB>) or normal control subjects. There was, also, a close correlation between CEA levels in GB bile and the tumor volume of liver metastases. So far as the H<SUB>0</SUB> patients were concerned, the increase in CEA levels in GB bile was attributable to either regional lymphnode metastasis or serum CEA levels. In conclusion, GB bile has more accurate diagnostic property than sera, for CEA from liver metastases is excreted in the bile. However, further clinical study is necessary to elucidate a role of GB bile in early detection of the hepatic recurrence after surgery for colorectal cancer.
日本大腸肛門病学会の論文