A case of mucinous cystadenoma of the appendix with cytofluorometric measurement of nuclear DNA.

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A case of mucinous cystadenoma of the appendix in a 68-year-old female is reported herein.<BR>The patient was referred to the Ryukyu University Hospital with a diagnosis of right lower quadrant mass of the abdomen. On admission, the mass was a fist in size, non-movable, and elastic hard with a smooth surface. CT and US showed a cystic tumor with calcification. The resected mass was 13 X 5 X 3 cm in size, cystic, and filled with mutinous material. Histologically, the tumor was cystadenoma with epithelial atypia. On mucin histochemistry, the mutinous substance was composed of acid mucin, mainly sialomucin. The nuclear DNA ploidy was diploid. On the other hand, mucinous cystadenocarcinoma revealed the same mucin profiles on the mucin histochemistry and its nuclear DNA ploidy was aneuploid.<BR>In mucinous cystic tumors, there is no definite interobserver agreement concerning the histologic degree of malignancy. DNA cytometry may be a valuable tool for differentiation of borderline and malignant tumors.
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